Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 1.503


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF3chr19_-_1652327-0.528.7e-17Click!
TCF4chr18_-_530687550.461.3e-12Click!
TCF12chr15_+_57210889,
chr15_+_57210852,
chr15_+_57210823
-0.448.5e-12Click!
TAL1chr1_-_476954420.101.2e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_195310985 83.474 NM_001647
APOD
apolipoprotein D
chr3_+_133494275 81.278 TF
transferrin
chr3_-_195310770 66.945 APOD
apolipoprotein D
chrX_+_103031753 62.015 NM_000533
NM_199478
PLP1

proteolipid protein 1

chrX_+_103031797 42.768 PLP1
proteolipid protein 1
chr10_-_73848530 41.622 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73848766 40.056 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr5_+_173472692 34.078 NM_015980
HMP19
HMP19 protein
chr16_+_2587989 31.603 PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_+_2588000 29.231 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_-_31514393 23.994 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr20_-_39766522 23.716


chr5_+_173472737 23.499 HMP19
HMP19 protein
chr18_+_21572736 22.152 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_+_111718006 21.451 NM_001008273
TAGLN3
transgelin 3
chr6_-_163148798 21.174 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr2_-_55277653 20.084 RTN4
reticulon 4
chr2_-_55277672 19.550 RTN4
reticulon 4
chr16_-_29910340 19.439 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr1_+_92632608 19.391 NM_015237
KIAA1107
KIAA1107
chr13_-_27334777 19.170 NM_005288
GPR12
G protein-coupled receptor 12
chrX_+_103031433 18.930 NM_001128834
PLP1
proteolipid protein 1
chr7_-_37025696 18.456 ELMO1
engulfment and cell motility 1
chr13_+_113741668 18.037 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_150738232 17.026 CTSS
cathepsin S
chr2_-_55277620 17.006 RTN4
reticulon 4
chr2_-_55277592 16.641 RTN4
reticulon 4
chr1_+_50569581 16.329 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_+_18208596 16.212 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr11_-_128894008 16.153 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_10068123 16.089 FANCD2
Fanconi anemia, complementation group D2
chr2_-_154335181 15.206 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_55277698 15.009 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr10_-_14050453 14.261 FRMD4A
FERM domain containing 4A
chr3_+_35722428 13.286 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_-_31514620 12.556 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr2_-_55277459 12.455 RTN4
reticulon 4
chrX_-_34675366 12.348 NM_031442
TMEM47
transmembrane protein 47
chr7_-_155437056 11.965


chr9_-_130667571 11.362 LOC100131355
ST6GALNAC6
uncharacterized LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr11_+_46694514 10.575 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr3_+_10068097 10.309 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr12_-_2944149 9.395 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr1_+_50571963 9.361 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr9_+_103204187 9.208 NM_001198812
C9orf30-TMEFF1
C9orf30
C9orf30-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr1_-_150738255 9.207 CTSS
cathepsin S
chr1_-_170038055 9.188 NM_001204517
KIFAP3
kinesin-associated protein 3
chr6_+_163149001 9.180 NM_001080379
PACRG
PARK2 co-regulated
chr8_+_21911062 8.885 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_-_42690308 8.662 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr17_+_38119225 8.241 NM_178171
GSDMA
gasdermin A
chr12_+_120105656 8.061 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr13_+_97874704 8.054 MBNL2
muscleblind-like 2 (Drosophila)
chr19_+_15852200 7.744 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr11_-_85469043 7.661 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr16_+_2588021 7.009 PDPK1
3-phosphoinositide dependent protein kinase-1
chr11_+_35684418 6.989 TRIM44
tripartite motif containing 44
chr14_-_24423329 6.877 C14orf167
chromosome 14 open reading frame 167
chr11_-_66675334 6.801 NM_022172
PC
pyruvate carboxylase
chr2_+_233498206 6.774 NM_025202
EFHD1
EF-hand domain family, member D1
chr8_+_9413390 6.588 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chrX_+_128913881 6.581 NM_018990
SASH3
SAM and SH3 domain containing 3
chr6_+_126240369 6.476 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr6_-_31514313 6.325 ATP6V1G2-DDX39B
ATP6V1G2
ATP6V1G2-DDX39B readthrough (non-protein coding)
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr2_-_183903225 6.283 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr6_-_163148800 6.281 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr2_-_158300517 6.111 NM_004288
CYTIP
cytohesin 1 interacting protein
chr17_+_41003184 6.030 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_-_56406120 5.904 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr13_-_45048436 5.900 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr16_+_2587951 5.828 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr7_-_97881436 5.733 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr2_-_25466795 5.684 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr4_-_87028805 5.585 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr15_+_25101697 5.571 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_+_140220811 5.553 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr13_+_97874540 5.452 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr13_+_49794471 5.319 NM_001507
MLNR
motilin receptor
chr17_-_1090562 5.262 NM_001159746
ABR
active BCR-related gene
chr1_-_160681552 5.238 NM_001778
CD48
CD48 molecule
chr14_+_101295409 5.238 MEG3
maternally expressed 3 (non-protein coding)
chr2_+_136288953 5.210 NM_015361
R3HDM1
R3H domain containing 1
chr4_+_114214102 5.196 ANK2
ankyrin 2, neuronal
chr1_+_36772696 5.150 NM_024676
SH3D21
SH3 domain containing 21
chr12_-_48119224 5.082 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr1_-_51984994 5.003 NM_001981
EPS15
epidermal growth factor receptor pathway substrate 15
chr8_-_66701175 4.998 NM_002603
PDE7A
phosphodiesterase 7A
chr18_-_53068755 4.933 TCF4
transcription factor 4
chr3_+_122296432 4.828 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr12_-_131002409 4.800 NM_015347
RIMBP2
RIMS binding protein 2
chr5_+_161275897 4.785 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_-_15918848 4.733 NM_013940
OR10H1
olfactory receptor, family 10, subfamily H, member 1
chr5_-_176326314 4.680 NM_002115
HK3
hexokinase 3 (white cell)
chr12_-_103311380 4.597 NM_000277
PAH
phenylalanine hydroxylase
chr19_-_39368889 4.480 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr19_-_12997956 4.471 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr6_+_36210944 4.366 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr19_-_4302381 4.320 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr1_-_23521221 4.270 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr18_+_29171729 4.233 NM_000371
TTR
transthyretin
chr11_+_67222817 4.192 NM_145200
CABP4
calcium binding protein 4
chr3_-_10067989 4.158 CIDECP
cell death-inducing DFFA-like effector c pseudogene
chr18_+_77439843 4.133 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr5_+_155754172 4.078 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr6_-_41703938 4.077 NM_001167827
TFEB
transcription factor EB
chrX_+_110339374 4.072 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr8_+_136470108 4.025 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr4_+_88742549 4.001 NM_001184694
MEPE
matrix extracellular phosphoglycoprotein
chrX_+_135067573 3.993 NM_001177651
NM_001042537
NM_006359
SLC9A6


solute carrier family 9 (sodium/hydrogen exchanger), member 6


chr3_-_120068077 3.992 NM_001099678
LRRC58
leucine rich repeat containing 58
chr17_+_14204326 3.969 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_-_226076766 3.869 NM_020997
LEFTY1
left-right determination factor 1
chr11_-_88796815 3.805 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr22_+_36649172 3.727 APOL1
apolipoprotein L, 1
chrX_+_128913897 3.643 SASH3
SAM and SH3 domain containing 3
chr11_-_71746966 3.581


chr19_-_14952688 3.556 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr5_-_88199868 3.553 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_166930130 3.526 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr6_+_29364331 3.468 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr5_+_147443534 3.365 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr17_-_56606534 3.356 SEPT4
septin 4
chr12_-_50236868 3.350 NM_181708
BCDIN3D
BCDIN3 domain containing
chr19_-_36499583 3.322 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr1_-_153013593 3.318 NM_006945
SPRR2D
small proline-rich protein 2D
chr1_-_114429996 3.317 BCL2L15
BCL2-like 15
chr14_-_94849552 3.312 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_+_32716839 3.278 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr15_+_91447419 3.271 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr8_+_9413439 3.259 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr6_-_46889620 3.221 NM_001098518
GPR116
G protein-coupled receptor 116
chr16_-_71610948 3.167 NM_000353
TAT
tyrosine aminotransferase
chr2_-_55277421 3.156 RTN4
reticulon 4
chr19_+_15838833 3.064 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr19_-_11688441 3.052 ACP5
acid phosphatase 5, tartrate resistant
chr10_+_11206928 2.843 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr19_+_45417920 2.834 NM_001645
APOC1
apolipoprotein C-I
chr3_-_114478117 2.752 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr10_+_7745325 2.750 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr22_+_40322609 2.750 GRAP2
GRB2-related adaptor protein 2
chr19_+_17516502 2.729 LOC100507535
uncharacterized LOC100507535
chr10_+_7745229 2.718 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_-_15601574 2.702 NM_001004320
AGMO
alkylglycerol monooxygenase
chr2_+_233271551 2.666 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr19_-_51472816 2.638 NM_002774
KLK6
kallikrein-related peptidase 6
chr20_+_60174816 2.637 NM_001252339
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr14_+_71996041 2.572 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr3_-_51996855 2.496 NM_033010
PCBP4
poly(rC) binding protein 4
chr10_+_95517565 2.476 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr13_+_97928196 2.457 MBNL2
muscleblind-like 2 (Drosophila)
chr17_-_67311773 2.444 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr2_-_25467078 2.395 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr22_-_36556781 2.364 NM_145640
APOL3
apolipoprotein L, 3
chr7_+_26403944 2.307 NM_001199838
SNX10
sorting nexin 10
chr10_+_7745284 2.260 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_191301020 2.239 MFSD6
major facilitator superfamily domain containing 6
chrX_+_48242967 2.207 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chrX_-_48056198 2.203 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr2_-_86850959 2.158 NM_001198951
NM_001198952
NM_005667
RNF103


ring finger protein 103


chr10_+_7745341 2.113 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_69434215 2.103 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr11_+_2323356 2.059 TSPAN32
tetraspanin 32
chr16_+_68279297 2.047 PLA2G15
phospholipase A2, group XV
chr7_-_44105162 2.004 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr15_+_74900712 1.999 NM_003992
CLK3
CDC-like kinase 3
chr12_+_12764755 1.983 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr11_+_61891414 1.983 NM_001040694
NM_020238
INCENP

inner centromere protein antigens 135/155kDa

chr22_+_31003069 1.935 NM_000355
NM_001184726
TCN2

transcobalamin II

chr19_-_11688484 1.935 ACP5
acid phosphatase 5, tartrate resistant
chr12_-_8219001 1.904 C3AR1
complement component 3a receptor 1
chr14_-_94759556 1.873 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr11_+_1213469 1.872 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr1_+_244216506 1.843 NM_006352
ZNF238
zinc finger protein 238
chr11_+_2323236 1.830 NM_139022
TSPAN32
tetraspanin 32
chr8_-_38239466 1.829 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr20_-_45061554 1.813 ELMO2
engulfment and cell motility 2
chr1_-_92951593 1.744 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr1_+_86934525 1.737 NM_001285
CLCA1
chloride channel accessory 1
chr9_-_8733893 1.718 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr19_-_14992166 1.698 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr7_+_18548899 1.687 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr19_+_16059817 1.686 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr17_-_38073792 1.602 NM_018530
GSDMB
gasdermin B
chr7_+_90338711 1.558 NM_012395
CDK14
cyclin-dependent kinase 14
chr10_+_86004808 1.555 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr19_-_33360641 1.552 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr5_+_53751430 1.526 NM_006308
HSPB3
heat shock 27kDa protein 3
chr18_+_32335939 1.516 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr11_+_72980938 1.460 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_+_47840370 1.458 NM_018485
GPR77
G protein-coupled receptor 77
chr3_-_187454247 1.442 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chrX_-_32430370 1.440 NM_004011
NM_004012
DMD

dystrophin

chr19_-_11688508 1.420 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr1_-_114430168 1.416 NM_001010922
BCL2L15
BCL2-like 15
chr16_+_77224827 1.403 NM_014940
MON1B
MON1 homolog B (yeast)
chr19_+_46195740 1.360 NM_001163377
NM_017659
QPCTL

glutaminyl-peptide cyclotransferase-like

chr11_+_58346636 1.337 ZFP91-CNTF
ZFP91
ZFP91-CNTF readthrough
zinc finger protein 91 homolog (mouse)
chr18_+_56530060 1.335 NM_018181
ZNF532
zinc finger protein 532
chr20_-_1638359 1.304 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr11_-_55703875 1.273 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 6.40e-04 GO:0050896 response to stimulus
1.84 1.38e-02 GO:0065008 regulation of biological quality
1.43 4.39e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 6.68e-03 GO:0071944 cell periphery
1.48 1.27e-02 GO:0005886 plasma membrane

Nothing significant found in function category.